The Nottinghamshire-based official will travel to Moss Rose for his fourth game of the season.
The Select Group Two referee is back in the middle after a long injury lay-off which kept him out of action from April 2017 until March 2019, missing the entirety of 2017-18 and taking charge of just one league encounter in 2018-19.
Prior to his injury, Adcock was a regular match official in the Championship and completed the 2016-17 season having taken charge of 28 games, showing 88 yellow cards and two reds.
He's refereed the Iron on four occasions in total, most recently in October 2014 at Vale Park. He showed five yellow cards and one red on that night, with the dismissal going to Jennison Myrie-Williams on his return to his former club. In total, across the four games, he's shown 18 yellow cards and three reds.
Meanwhile, he's taken charge of Macclesfield Town on two occasions - their most recent being a 2-0 defeat at Southend United back in May 2012. His only othe game involving them came in a slender home defeat to Wycombe Wanderers in February 2011 where three red cards were shown in stoppage time.
So far in this campaign, he has officiated in three encounters, showing 17 yellows and one red.
On Saturday, Adcock will be assisted by Mark Jones and Paul Hodskinson, while Elliott Swallow has been appointed as the fourth official.
PAST SCUNTHORPE UNITED ENCOUNTERS
| DATE | COMP | MATCH | Y | R |
| Oct 21, 2014 | LG 1 | Port Vale 2-2 Iron | 5 | 1 |
| Mar 29, 2014 | LG 2 | Iron 0-0 Wycombe Wanderers | 3 | 0 |
| Aug 25, 2012 | LG 1 | Iron 0-4 Yeovil Town | 6 | 0 |
| Mar 6, 2012 | LG 1 | Oldham Athletic 1-2 Iron | 4 | 2 |
PAST MACCLESFIELD TOWN ENCOUNTERS
| DATE | COMP | MATCH | Y | R |
| May 5, 2012 | LG 2 | Southend United 2-0 Macclesfield Town | 3 | 0 |
| Feb 26, 2011 | LG 2 | Macclesfield Town 0-1 Wycombe Wanderers | 2 | 3 |
