The Iron are 4/5 with Sky Bet to defeat Bradford City at Glanford Park on Saturday.
A draw is available at 5/2, while an away win is 16/5.
United need the three points and can be backed at 15/2 to record a 2-0 win, making it back-to-back home clean sheets.
Lee Novak is 10/3 to open the scoring, while Kevin van Veen and Kyle Wootton can be backed at 5/1. Rory McArdle is 40/1 to net the first goal, and his first of the season, against his former club.
There are also Multi Scorer options available - for instance Novak is 6/1 to net a brace and 33/1 to hit a hat-trick.
In addition, there are Match Specials available, with Scunthorpe to score two in the first half at 4/1 and United 5/1 to net in the first ten minutes.
For more odds ahead of the game, click here, and remember that every bet placed benefits the club financially.