Rory Watson, Neal Bishop, Hakeeb Adelakun and Tom Hopper replace Matt Gilks, Levi Sutton, Conor Townsend and Lee Novak.
Portsmouth: McGee, Clarke, Burgess, Pitman, Hawkins, Ronan, Donohue, Lowe, Thompson, Naismith, Close.
Substitutes: Bass, Kennedy, Chaplin, Bennett, Deslandes, May, Casey.
Scunthorpe United: Watson, Wallace, Ojo, van Veen, Morris, Bishop, Hopper, Adelakun, Holmes, Goode, Burgess.
Substitutes: Kelsey, Townsend, Toney, Novak, Sutton, McArdle, McGeehan.
