The Lincolnshire-based official will travel to Glanford Park for his 23rd game of the campaign and his 9th in Sky Bet League One.
His first game of the campaign was Rochdale's 2-1 away win at Burton Albion in which he showed three yellow cards. Meanwhile, his latest encounter came a week ago when he took charge of the goalless League Two encounter between Macclesfield Town and Port Vale.
He's taken charge of the Iron on eight occasions in total, most recently in October when he oversaw the 5-3 home victory over Charlton Athletic. He showed five yellow cards in that game.
Of those encounters involving United, five of them have come at Glanford Park, so Saturday will be Drysdale's sixth appointment with the whistle at the stadium. In the eight games refereeing Scunthorpe, he's issued 25 yellow cards and no red.
Meanwhile, he's refereed Wycombe Wanderers on 13 occasions - most recently back in September when the Chairboys edged a 1-0 victory at Northampton Town in the Checkatrade Trophy. He showed four cautions in the game.
In 2017-18, he took charge of 46 games, issuing 143 yellow cards and six red. So far in this campaign, he has officiated in 22 encounters, showing 82 yellows and three reds.
On Saturday, Drysdale will be assisted by David Plowright and Declan Ford, while Billy Khatib has been appointed as the fourth official.
PAST SCUNTHORPE ENCOUNTERS
| DATE | COMP | MATCH | Y | R |
| Oct 2, 2018 | LG 1 | Iron 5-3 Charlton Athletic | 5 | 0 |
| Mar 30, 2018 | LG 1 | Oxford United 1-1 Iron | 7 | 0 |
| Aug 29, 2017 | EFLT | Iron 3-1 Sunderland U21 | 3 | 0 |
| Apr 17, 2017 | LG 1 | Iron 3-1 Chesterfield | 1 | 0 |
| Dec 6, 2016 | EFLT | Iron 1-1 Morecambe | 1 | 0 |
| Mar 25, 2015 | LG 1 | Barnsley 0-0 Iron | 3 | 0 |
| Mar 15, 2014 | LG 1 | Plymouth Argyle 0-2 Iron | 2 | 0 |
| Aug 13, 2011 | LG 1 | Iron 1-1 Preston North End | 3 | 0 |
PAST WYCOMBE WANDERERS ENCOUNTERS
| DATE | COMP | MATCH | Y | R |
| Sep 4, 2018 | FLT | Northampton Town 0-1 Wycombe Wanderers | 4 | 0 |
| Apr 21, 2018 | LG 2 | Wycombe Wanderers 0-4 Accrington Stanley | 1 | 0 |
| Apr 29, 2017 | LG 2 | Morecambe 1-1 Wycombe Wanderers | 4 | 0 |
| Feb 18, 2017 | LG 2 | Wycombe Wanderers 1-2 Carlisle United | 5 | 0 |
| Dec 28, 2015 | LG 2 | Wycombe Wanderers 2-0 Crawley Town | 1 | 0 |
| Dec 4, 2013 | LG 2 | Portsmouth 2-2 Wycombe Wanderers | 6 | 0 |
| Oct 6, 2012 | LG 2 | Wycombe Wanderers 2-1 Torquay United | 2 | 0 |
| Oct 15, 2011 | LG 1 | Hartlepool United 1-3 Wycombe Wanderers | 1 | 0 |
| Mar 5, 2011 | LG 2 | Wycombe Wanderers 2-2 Aldershot Town | 4 | 0 |
| Aug 16, 2008 | LG 2 | Chester 0-2 Wycombe Wanderers | 4 | 0 |
| Jan 6, 2007 | LG 2 | Wycombe Wanderers 1-1 Rochdale | 4 | 0 |
| Nov 26, 2005 | LG 2 | Carlisle United 0-1 Wycombe Wanderers | 2 | 0 |
| Apr 30, 2005 | LG 2 | Wycombe Wanderers 3-2 Leyton Orient | 7 | 0 |
