The Iron can be backed at 2/1 with Sky Bet to defeat Salford City at the Sands Venue Stadium on Tuesday night.
A draw is 23/10, with an away success available at 5/4.
We've only met them once before, drawing 1-1 at the Peninsula Stadium last season and it's 11/2 for a repeat of that.
Fancy a 2-0 home win? That can be backed at 14/1. Indeed, in the 'Correct Score Group Betting' odds, Scunthorpe to win 1-0, 2-0 or 2-1 is 10/3, while the Iron to be 3-0, 3-1 or 3-2 victors is 10/1.
Abo Eisa is favourite for first United goal at 11/2, with John McAtee 13/2 to score against his hometown team. Ryan Loft is available at the same odds. Fancy an outside bet? Jem Karacan is 16/1, with George Taft 50/1.
For more odds ahead of the match, click here and remember every bet placed benefits your club financially.