The Iron have been installed at 15/8 with Sky Bet to record back-to-back wins and overhaul Port Vale at Vale Park this weekend.
The home side are currently priced at 7/5 to take all three points, while a draw is 21/10.
United are without a win at Vale Park since February 2006, with the last a 2-1 win following goals from Matt Sparrow and Cleveland Taylor. Sky Bet have a 2-1 away win priced at 10/1.
The reverse fixture at the Sands Venue Stadium earlier this season was also the same scoreline in favour of Scunthorpe following goals from Kevin van Veen and Kgosi Ntlhe. Vale are priced at 9/1 to get their revenge with their own 2-1 home win.
Port Vale come into the match six unbeaten in League Two, winning four of those matches. They're also seven unbeaten on home soil with their most recent home win 3-0 against Colchester. Sky Bet have them at 22/1 to repeat the feat.
Sky Bet have a number of correct score group bets available on the dedicated fixture page for this match, with Scunthorpe to win 1-0, 2-0 or 2-1 priced at 11/4, while a 1-1, 2-2 or 3-3 draw currently at 10/3.
For more odds, click here and remember that every bet placed benefits the club financially.