The Iron are 12/5 with Sky Bet to record victory over Sunderland in the Leasing.com Trophy and progress to Round Two.
The away side can be backed at 23/20, while a draw - which will also see Scunthorpe progress - is available at 5/2.
It was 1-1 the last time the sides met back in January, with Sky Bet pricing a repeat scoreline at 6/1.
Ryan Colclough got the side's goal in the second group stage match against Leicester City Under-21s. He's 14/1 to be first or last goalscorer and 5/1 to net anytime.
For more odds, click here and remember that every bet placed benefits the club financially.