The home side can be backed at 8/13, while a draw is also predicted at 11/4.
The last meeting at Fratton Park came in January last year, with the teams playing out a 1-1 draw, and if you think it will be a similar scoreline this time around, then a full-time result of 1-1, 2-2 or 3-3 is seen at 7/2.
However, the Iron have a good record against Pompey of late and have only lost one of their last six games against them.
So, if you fancy the Iron to bag all three points again this weekend, then Scunthorpe to win 1-0, 2-0 or 2-1 is priced at 11/2, whilst a scoreline 3-0, 3-1 or 3-2 is forecasted at 22/1.
Lee Novak leads the way as the Iron’s predicted first goalscorer on Saturday at 13/2, with Kyle Wootton following closely behind at 8/1.
Meanwhile, Scunthorpe to win and both teams to score is backed at 10/1.
For more great odds ahead of the game, click here and remember that every bet placed benefits the club financially.