A draw is available at 13/5, while an away win is also at the same odds.
United were 2-0 winners last time they played host to the Pilgrims in May, and can be backed at 9/1 to repeat that.
Think Andy Dales can get his first home goal in Scunthorpe colours? He is available at 11/2, while George Thomas, Ike Ugbo and Stephen Humphrys can be backed at the same odds too. Lee Novak is favourite at 9/2.
Meanwhile, an Iron clean sheet is available at 15/8.
For more odds ahead of the game, visit www.skybet.com/scunthorpe and remember that every bet placed benefits the club financially.