Sky Bet have the Iron at 4/1 to beat Barnsley at Glanford Park on Saturday as they look to register their first home victory of the season.
An away win for the visitors can be backed at 8/11, whilst a draw can be seen at 13/5.
Meanwhile, Scunthorpe to win and both teams to score has been boosted from 9/1 to 11/1 with Lee Novak and Andy Dales the favourites to net the opener for United, both at 15/2.
As the Iron look for a quick response following defeat last time out, Sky Bet have them at 10/1 to score in the opening ten minutes of the game, whilst a Scunthorpe victory by a scoreline of 1-0, 2-0 or 2-1 have odds at 5/1.
For more great odds ahead of the game, visit www.skybet.com/scunthorpe and remember that every bet placed benefits the club financially.