The Iron are 3/4 odds-on favourites to progress to round two of the Carabao Cup.
The visitors can be backed at 18/5 for a win, while a draw after 90 minutes is 11/4.
United won this corresponding fixture at Glanford Park 2-0 last season, with the two sides again drawn to meet at this stage of the competition. Kevin van Veen notched a brace in extra time to see off the Magpies.
Should the game go to extra time once more, Scunthorpe are 4/11 to win over the course of 120 minutes or on penalties, while Notts County are 2/1 to go through to round two with the need of more than normal time.