The Iron will head to Somerset for the match with Yeovil, in search of a reaction from the loss to Fleetwood.United could be missing midfielder Neal Bishop, who is regarded as a 'major doubt' by boss Russ Wilcox after a deep cut to his thigh in midweek against the Cod Army.
Nicky Featherstone has linked up with the club on a week-to-week basis and comes into the squad.
Billy Kee, who joined from Burton on a three-year deal on Monday, could start after making a substitute appearance just over 24 hours after joining.
Bobby Olejnik is expected to continue in goal for the Iron, after injuries to Sam Slocombe and James Severn make him the only experienced fully fit keeper, with youth product Pat Weaver ready and waiting in the wings as back-up to the Austrian.
Slocombe faces around a fortnight out after a trip to a specialist, while Severn could be out for six to eight weeks with a thigh strain and Peterborough fans’ Player of the Year last season has arrived on a one-month loan.
It will be the 15th meeting between the two sides, with the Iron winning eight previous ties, drawing once and losing five times.
The last meeting was in 2012/13, when Yeovil won 3-0 at Huish Park months after leaving Glanford Park 4-0 winners.
We last beat them in September 2011, when a Damien Mozika double helped us to a 2-1 win.
Yeovil won their first match on Tuesday evening, with a 2-1 win at Walsall after losing their opening league games to Gillingham and Doncaster.
The Iron will go there keen to get some points on the board and Russ Wilcox’s men will travel down on Friday in preparation for the Saturday match without a number of faces.
While Marcus Williams returns from suspension, we will be without Sam Slocombe, James Severn, David Mirfin and Dave Syers.
Yeovil are managed by Gary Johnson and they are also in their first season back in Sky Bet League One, after relegation from the Championship last term.
It also represents a return to an old stomping ground for Paddy Madden, who joined the Iron from Yeovil last January.
Paddy made nearly 50 appearances for the Glovers and in his final full season he got the golden boot in League One, firing his side to promotion via the play-offs and hopefully he could repeat history with the Iron.
Huish Park can hold nearly 10,000 fans and over 5,000 of them are seated and it will be great to see the Iron travel down in their numbers once again to cheer on the Claret and Blue.
Scunny are 23/10 for the win and 12/5 for the draw, with the home side edging it as they are rated 21/10 favourites for the win with the league’s official betting partner SkyBet.
See our Betting Preview article for more in-depth odds analysis of our game and you can find it on the website before the weeknd match, which kicks off at 3.00pm on Saturday.
If you aren’t making the long trip to Huish Park at the weekend, keep track of the action by tuning into the club’s official social media channels or keep an eye on events on the website, with live updates available from kick-off.
Here are the fixtures elsewhere in the division this weekend:
Barnsley v Gillingham
Bradford v Peterborough
Colchester v Doncaster
Fleetwood v Chesterfield
Leyton Orient v Walsall
MK Dons v Coventry
Port Vale v Notts County
Preston v Oldham
Rochdale v Bristol City
Sheff Utd v Crawley
Swindon v Crewe